Evaluation of Cuban red propolis extract on liver sinusoidal endothelial cell cultures

Autores/as

  • Sandra Rodríguez National Center for Scientific Research
  • Filip Braet Free University of Brussels (VUB)
  • Marijke Baekeland Free University of Brussels (VUB)
  • Carine Seynaeve Free University of Brussels (VUB)
  • Danielle Blijweert Free University of Brussels (VUB)
  • Ronald De Zanger Free University of Brussels (VUB)
  • Mario Fajardo National Apicultural Station
  • Eddie Wisse Free University of Brussels (VUB)

Resumen

An ethanol extract of Cuban red propolis (CRP), mainly composed of naphtoquinones,1 has been reported to possess scavenging action against oxygen radicals as well as hepatoprotective and anti-inflammatory effects on animal models. 2-6 The 1:4- naphtoquinones-propolis derived fraction exerts scavenging action against oxygen radicals and inhibits tertbutyl/Fe2+-induced lipid peroxidation in rat microsomes. Five types of cells constitute the liver functional unit. They are divided into parenchymal cells or
hepatocytes and non-parenchymal cells or sinusoidal cells. The sinusoidal cells are composed by fenestrated sinusoidal endothelial cells, Kupffer cells or liver macrophages, fat-storing cells or liver fibroblasts, and pit cells or liver NK cells. Each of them has a specific ultrastructure and function, directly related to their functions. In addition, they display different reactions against induced liver damage or disease.8 From the morphological point of view, CRP extract induces recovery of hepatocytes structure until nearly normal conditions in rodents after acute induced liver damage in centrolobular and periportal liver regions,3-6 but its effect on non parenchymal cells has not been studied before.

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Publicado

2022-05-05

Cómo citar

Rodríguez, S. ., Braet, F. ., Baekeland, M. ., Seynaeve, C. ., Blijweert, D. ., De Zanger, R. ., Fajardo, M. ., & Wisse, E. . (2022). Evaluation of Cuban red propolis extract on liver sinusoidal endothelial cell cultures. Revista CENIC Ciencias Biológicas, 31(2), 098-102. Recuperado a partir de https://revista.cnic.cu/index.php/RevBiol/article/view/1370

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Sección

Comunicaciones cortas

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