Reproductive toxicity of d-004 (a lipid extract from roystonea regia fruits) in rats

Autores/as

  • Ariadne Gutiérrez-Martínez Center of Natural Products. National Center for Scientific Research
  • Balia Pardo-Acosta Center of Natural Products. National Center for Scientific Research
  • Rafael Gámez-Menéndez Center of Natural Products. National Center for Scientific Research
  • Rosa Mas-Ferreiro Center of Natural Products. National Center for Scientific Research
  • Gisela Marrero-Cofiño Center of Natural Products. National Center for Scientific Research
  • Daniel Arencibia-Arrebola Center of Natural Products. National Center for Scientific Research
  • Haydee García-Cambián Center of Natural Products. National Center for Scientific Research
  • Dayisell Curveco-Sánchez

Palabras clave:

D-004, Roystonea regia, free fatty acids, reproductive toxicity, rats

Resumen

D-004 is a lipid extract of Roystonea regia (royal palm) fruits that consists in a mixture of free fatty acids that prevents prostate hyperplasia induced with testosterone in rodents. D-004 has shown to inhibit the enzyme activity of prostate 5--reductase in vitro. The objective of this study was investigate the possible reproductive toxicity of D-004 administered to fertile Sprague Dawley rats of both sexes. Rats were randomised into four groups: a control group, treated with the vehicle and three groups with D-004 at 500, 750 or 1 000 mg/kg/d, respectively. Female rats were treated for 15 d prior mating, during mating and pregnancy, and until lactation (day 21). Male rats were treated 10 weeks before and during mating. No evidence of D-004-related toxicity was observed. Thus, maternal body weight and food consumption, litter size, survival through the weaning period and weights of male and female pups did not show differences between control and treated groups. Drug-treated and control groups offspring were comparable in both physical and sensorial development and in reproductive performance. There were no significant differences among F2 generation groups in the number of born pups, mean pup’s weight and postnatal pup’s survival. It is concluded that D-004 orally administered to rats of both sexes did not affect the fertility and general reproductive function, which indicates that it does not alter the lactation, growth, development and sexual maturation of the progeny.

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Publicado

2019-05-16

Cómo citar

Gutiérrez-Martínez, A., Pardo-Acosta, B., Gámez-Menéndez, R., Mas-Ferreiro, R., Marrero-Cofiño, G., Arencibia-Arrebola, D., García-Cambián, H., & Curveco-Sánchez, D. (2019). Reproductive toxicity of d-004 (a lipid extract from roystonea regia fruits) in rats. Revista CENIC Ciencias Biológicas, 49(2), 24-33. Recuperado a partir de https://revista.cnic.cu/index.php/RevBiol/article/view/188

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