Utilization de las microondas en ausencia de disolventes . 2-Oxazolinas, 2-imidazolinas y sus intermediarios

Abstract

This paper constitutes the first Cuban review on the use of micro­waves for purposes of chemical synthesis and its applications in Organic Chem­istry, starting from the experiences and purposes that the author has developed from 1991 in order to introduce and extend this novel technique in Cuba. A de­tailed discussion on the foundations, principies, scope, interest, advantages, limi­tations and potentialities of the use of these methodologies in relation to the tra­ditional methods of synthesis is presented. The possibilities of using this tech­nique in tandem-condensation-cyclodehydration intramolecular reactions with­out solvent (as a result of a very particular form of activation by to the harmoniza­tion of complementary effects in microwaves), have been adjusted to a wide vari­ety of reactions between carboxylic acids and aminoalcohols or diamines and to the obtainment of families of compounds of interest for multiple industrial and scientific applications, that allow to show the state of the art and development on microwaves applications for scientific and preparative purposes, which have a novel place inside the international classification of this kind of works. The pro­posal to extend these methodologies to the Cuban scientific-technical develop­ment is supported on its undoubted practica! advantages frorn an economic point ofview, as for saving ofraw materials, energy, time and solvents, which is particu­larly adjusted to the present economic situation of this country.