Síntesis de derivados halogenados a insaturados del pregnano

Abstract

Most of the antiandrogens are steroidal derivatives which bave a wide use on tbe treatment of severa! illness. It is known that a halogen atom produces changes in the androgenic activity but these cbanges are bigger when a bromine atom is used. This atom affects more than 4-en-3-keto system whicb is partialy responsible for the activity. There are many drugs witb antiandrogenic properties that are useful on the treatment of many diseases related to andro­genic disfunctions. One of the most important is the ciproterone acetate, but its employment is restricted due to its partial progestational activity. In fact, the study of new alternatives would belp to improve their uses as antiandrogens in clinical therapy. These options have to decrease tbe side effects and increase tbeir capacity-power. The synthesis ofhalogenated compounds of the pregnane's serie with possible antiandrogenic activity was the main objectives of this paper.