Recent advances in the analytical determination of cisplatin and its hydrolysis products

Abstract

Cisplatin (cis-diaminedichloroplatinum [II]) is a coordination compound, used in the treatment of several
solid tumors. Cisplatin and its hydrolysis products exhibit a great pharmacological effect but are very toxic and probably
carcinogenic. The present review summarizes the most important advances in the last years in the techniques employed
for the detection and quantification of cisplatin and its hydrolysis products and in the different matrixes studied. The
new emerging techniques and their modifications recently developed, fundamentally the combined use of detection and
separation techniques for the analysis of platinum species and their impact on the speed, sensitivity and specificity of the
analytical determination, with regard to the techniques used in the last century are discussed. High-Performance Liquid
Chromatography and Capillary Electrophoresis, coupled with detection methods such as Mass Spectrometry, Inductively
Coupled Plasma–Mass Spectrometry, Atomic Absorption Spectrometry and more recently, High-Field Asymmetric Waveform
Ion Mobility Spectrometry are the methods more employed. The analysis of cisplatin and its hydrolysis products in
new and more complex matrixes is also presented.