Effectiveness of ozonized cocoa butter for the treatment of vaginal candidiasis

Authors

  • Irene Lezcano Centro de Investigaciones del Ozono
  • Gastón García Instituto de Farmacia y Alimentos, Universidad de La Habana
  • Gerardo Martínez Instituto "Pedro Kourí"
  • Jesús x Jesús Molerio Centro de Investigaciones del Ozono
  • Zullyt Zamora Centro de Investigaciones del Ozono
  • Carlos Fernández Instituto "Pedro Kourí"
  • Addys González Centro Nacional de Investigaciones Científicas
  • Daily Castañeda Centro de Investigaciones del Ozono

Abstract

Candida vaginitis continues to be a prevalent disease with a world-wide distribution. Some ozonized substances as: sunflower oil and cacao butter have shown antimicrobial effects against Candida albicans. Lately, sev-eral experimental models of candidosis in mice and rats have been developed. The purpose of this study was to determine the effectiveness of ozonized cacao butter to treat vaginal candidosis. Candida vaginitis in Sprague-Dawley rats were developed with an inoculum of 106 Candida albicans 3153 in 0.1 mL of phosphate buffer solution. Six groups of infected animals were studied: three different doses of ozonized cacao butter ovules and three control groups; one was treated with ketoconazol ovules, another with untreated cacao butter ovules and the last one without treatment. The experimental model used in this paper allowed to develop vaginal candidosis in 80 % of inoculated rats; it made possible to study the effectiveness of ozonized cacao butter for the treatment of Candida vaginitis.

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Published

2022-11-14

How to Cite

Lezcano, I. ., García, G. ., Martínez, G. ., Jesús Molerio, J. x, Zamora, Z. ., Fernández, C. ., González, A. ., & Castañeda, D. . (2022). Effectiveness of ozonized cocoa butter for the treatment of vaginal candidiasis. NATIONAL CENTER FOR SCIENTIFIC RESEARCH (CENIC) BIOLOGICAL SCIENCES JOURNAL, 29(3), 206-208. Retrieved from https://revista.cnic.cu/index.php/RevBiol/article/view/2748

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Research articles

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