Modelo computacional del circuito motor basado en estudios de Resonancia Magnética Nuclear funcional

Abstract

The basal ganglia are a complex network of subcortical nuclei involved in motor control, sensorimotor integration,
and cognitive processes. Their functioning and interaction with other cerebral structures remains as a subject
of debate. The aim of the present work was to simulate the basal ganglia-thalamus-cortex circuitry interaction in motor
program selection, supported by functional connectivity pattern obtained by functional nuclear magnetic resonance
imaging. Determination of connections weights between neural populations by functional magnetic resonance imaging,
contributed to a more realistic formulation of the model; and consequently to obtain similar results to clinical and experimental
data. The network allowed to describe the participation of the basal ganglia in motor program selection and the
changes in Parkinson disease. The simulation allowed to demonstrate that dopamine depletion above to 40 % leads to a
loss of action selection capability, and to reflect the system adaptation ability to compensate dysfunction in Parkinson
disease, coincident with experimental and clinical studies.