STATE-OF-THE-ART ANTIMICROBIALS

Abstract

Currently, one of the priorities of the World Health Organization is antibiotic-resistant bacteria. Bacteria have a great capacity for dissemination and make it difficult to treat infectious diseases. It is known that they have high morbidity and mortality worldwide, which is considered a global public health problem. The objective is to carry out a documentary review of the latest generation antimicrobials, which may constitute a therapeutic alternative. An analysis of the information available and documented in the scientific literature consulted was carried out. The sampling was carried out between the years 2015-2022, to cover the last years. Google academic, PubMed and MDPI search engines were used as an infotechnology tool. At present there are new antibiotic alternatives among which are Ceftolozano-tazobactam, Ceftazidime-avibactam, Ceftaroline, Ceftobiprole, Dalbavancin, Telavancin, Tedizolid, Omadacycline, Delafloxacin and Lefamulin. Also, the use of peptides that have activity against bacterial, fungal or viral infections was confirmed, as well as bacteriophages that different studies have shown the efficacy of phage therapy against infections. In recent years, the scientific community has been attracted by the so-called photothermal therapy to combat pathogens (nanomaterials and metals), plant-derived antimicrobials and other advances such as bisphocins and hydrogels that can be used in the treatment of infections caused by antibiotic resistant bacteria. It is concluded that there are state-of-the-art antimicrobials that could be part, now or in the future, of a new therapeutic arsenal